Restless legs syndrome in Parkinson's disease and other neurodegenerative diseases of the central nervous system
Identifieur interne : 002C06 ( Main/Exploration ); précédent : 002C05; suivant : 002C07Restless legs syndrome in Parkinson's disease and other neurodegenerative diseases of the central nervous system
Auteurs : Alex Iranzo [Espagne] ; Cynthia L. Comella [États-Unis] ; Joan Santamaria [Espagne] ; Wolfgang Oertel [Allemagne]Source :
- Movement Disorders [ 0885-3185 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Central nervous system, Humans, Joseph disease, Machado–Joseph disease, Nervous system diseases, Neurodegenerative Diseases (complications), Parkinson Disease (complications), Parkinson disease, Parkinson's disease, Restless Legs Syndrome (complications), Restless Legs Syndrome (physiopathology), Restless legs syndrome, Spinocerebellar ataxia, autosomal dominant spinocerebellar ataxias, dopaminergic system, neurodegenerative diseases, restless legs syndrome.
- MESH :
- complications : Neurodegenerative Diseases, Parkinson Disease, Restless Legs Syndrome.
- physiopathology : Restless Legs Syndrome.
- Humans.
Abstract
The pathophysiology of restless legs syndrome (RLS) is associated with central dopaminergic system dysfunction leading to speculations that RLS may be common in those neurodegenerative diseases with dopaminergic cell loss. However, since RLS is a very common condition, the co‐occurrence with less frequent disorders such as the neurodegenerative diseases might be a matter of chance. Currently, no data suggests that patients with sporadic and familial RLS are at increased risk for developing a neurodegenerative disease. In particular, whether RLS is associated with Parkinson's disease has not been established. Only a few studies have directly addressed this issue, and these have methodological limitations yielding conflicting results. Few studies have assessed the frequency of RLS in other neurodegenerative disorders. In several autosomal dominant spinocerebellar ataxias, particularly in Machado‐Joseph disease, a higher frequency of RLS is reported than could be accounted for in the general population. Two anecdotal publications have reported the presence of RLS in patients with Huntington's disease and hereditary spastic paraparesis. There are no studies that have examined the association between RLS and other neurodegenerative diseases, such as Alzheimer's disease, frontotemporal dementia, dementia with Lewy bodies, multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration. © 2007 Movement Disorder Society
Url:
DOI: 10.1002/mds.21600
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2007">2007</date><biblScope unit="vol">22</biblScope><biblScope unit="issue">S18</biblScope><biblScope unit="supplement">S18</biblScope><biblScope unit="page" from="S424">S424</biblScope><biblScope unit="page" to="S430">S430</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">41D79A3AC267341773474CDCD01DC4032FBFE275</idno><idno type="DOI">10.1002/mds.21600</idno><idno type="ArticleID">MDS21600</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Central nervous system</term><term>Humans</term><term>Joseph disease</term><term>Machado–Joseph disease</term><term>Nervous system diseases</term><term>Neurodegenerative Diseases (complications)</term><term>Parkinson Disease (complications)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Restless Legs Syndrome (complications)</term><term>Restless Legs Syndrome (physiopathology)</term><term>Restless legs syndrome</term><term>Spinocerebellar ataxia</term><term>autosomal dominant spinocerebellar ataxias</term><term>dopaminergic system</term><term>neurodegenerative diseases</term><term>restless legs syndrome</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Neurodegenerative Diseases</term><term>Parkinson Disease</term><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Restless Legs Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Ataxie spinocérébelleuse</term><term>Maladie de Joseph</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Syndrome des jambes sans repos</term><term>Système nerveux central</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The pathophysiology of restless legs syndrome (RLS) is associated with central dopaminergic system dysfunction leading to speculations that RLS may be common in those neurodegenerative diseases with dopaminergic cell loss. However, since RLS is a very common condition, the co‐occurrence with less frequent disorders such as the neurodegenerative diseases might be a matter of chance. Currently, no data suggests that patients with sporadic and familial RLS are at increased risk for developing a neurodegenerative disease. In particular, whether RLS is associated with Parkinson's disease has not been established. Only a few studies have directly addressed this issue, and these have methodological limitations yielding conflicting results. Few studies have assessed the frequency of RLS in other neurodegenerative disorders. In several autosomal dominant spinocerebellar ataxias, particularly in Machado‐Joseph disease, a higher frequency of RLS is reported than could be accounted for in the general population. Two anecdotal publications have reported the presence of RLS in patients with Huntington's disease and hereditary spastic paraparesis. There are no studies that have examined the association between RLS and other neurodegenerative diseases, such as Alzheimer's disease, frontotemporal dementia, dementia with Lewy bodies, multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration. © 2007 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Espagne</li><li>États-Unis</li></country><region><li>Catalogne</li><li>Illinois</li></region><settlement><li>Barcelone</li></settlement></list><tree><country name="Espagne"><region name="Catalogne"><name sortKey="Iranzo, Alex" sort="Iranzo, Alex" uniqKey="Iranzo A" first="Alex" last="Iranzo">Alex Iranzo</name></region><name sortKey="Santamaria, Joan" sort="Santamaria, Joan" uniqKey="Santamaria J" first="Joan" last="Santamaria">Joan Santamaria</name></country><country name="États-Unis"><region name="Illinois"><name sortKey="Comella, Cynthia L" sort="Comella, Cynthia L" uniqKey="Comella C" first="Cynthia L." last="Comella">Cynthia L. Comella</name></region></country><country name="Allemagne"><noRegion><name sortKey="Oertel, Wolfgang" sort="Oertel, Wolfgang" uniqKey="Oertel W" first="Wolfgang" last="Oertel">Wolfgang Oertel</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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